Cocarcinogenicity of Phenols from Estonian Shale Tars (Oils)
نویسندگان
چکیده
منابع مشابه
Cocarcinogenicity of phenols from Estonian shale tars (oils).
Many phenols have carcinogenic activity. The Estonian shale oils contain up to 40 vol % phenols. The promoting activity after initiation of phenols of Estonian shale oils was tested in mice with a single subthreshold dose (0.36 mg) of benzo(a)pyrene. C57Bl and CC57Br mice were used in skin painting experiments. Weak carcinogenic activity was found in the total crude water-soluble phenols recove...
متن کاملCarcinogenicity studies of Estonian oil shale soots.
Several series of chronic experiments in white mice and white rats were carried out in order to determine the carcinogenicity of Estonian oil shale soot as well as the soot from oil shale fuel oil. All the investigated samples of soot showed a relatively low (from 14 to 1200 ppm) benzo(a)pyrene content. The benzene extract of oil shale soot, painted on the skin of white mice, proved to be stron...
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A review of morphological investigations carried out to clarify the pathogenicity of industrial dust produced in the mining and processing of Estonian oil shale is given. Histological examination of lungs of workers in the oil shale industry taken at necropsies showed that the inhalation of oil shale dust over a long period (more than 20 years) may cause the development of occupational pneumoco...
متن کاملToxicological studies of shale oils, some of their components, and commercial products.
Estonian shale oil contains about 25--30% phenols, and their action determines the toxicity of shale oils. The clinical symptoms of intoxication are rather similar, regardless of route of administration. Due to neurotropic action, the coordination of movements is impaired, and clonic and tetanic convulsions, paresis and paralysis of extremities, and narcosis are observed. In subacute and chroni...
متن کاملCarcinogenicity of oil shale tars, some of their components, and commercial products.
Bioassays for carcinogenicity of various primary processing products (crude oils or tars) and commercial products obtained from Estorian oil shale have been carried out since 1951. The products (undiluted or diluted) were painted twice weekly 50 times on the interscapular area of the skin of random-bred or CC57Br mice. The products processed at high temperatures have a higher carcinogenic activ...
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ژورنال
عنوان ژورنال: Environmental Health Perspectives
سال: 1979
ISSN: 0091-6765
DOI: 10.2307/3429121